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SICEM2021

Today : 2025.04.05

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Symposium

Symposium 1: Thyroid Function and QoL Day 2, October 29(Fri), 2021 / 09:30-11:00 / Room 1 / LIVE Overview
Organizer: Sun Wook KIM (Sungkyunkwan University)
Thyroid disease is one of the common chronic endocrine disorders affecting nearly 4-5 % of the general population. At this symposium, three experts will give us talks about thyroid hormone and quality of life, and its appropriate management. Professor Hong Jin Jeon at Samsung Medical Center, Seoul, Korea will talk about thyroid function and psychiatric problems. Professor Jacqueline Jonklaas from Georgetown University, USA will give us a lecture on the strategies for the optimal management of hypothyroidism. Finally, Professor Jie Li from Sun Yat-sen University, China will present QoL in thyroid cancer survivors.

Chairperson : Young Joo PARK (Seoul National University, Korea), Ka Hee YI (Seoul National University, Korea)

Hong Jin JEON 09:30-09:50 Thyroid Function and Psychiatric Diseases Hong Jin JEON (Department of Psychiatry, Sungkyunkwan University, Korea)
Jacqueline JONKLAAS 09:50-10:10 Optimization of Therapy for Hypothyroidism Jacqueline JONKLAAS (Georgetown University, USA)
Jie LI 10:10-10:30 Quality of Life of Differentiated Thyroid Cancer Survivors Jie LI (The First Affiliated Hospital, Sun Yat-sen University, China)
Panel Discussion
10:30-11:00 Eyun SONG Eyun SONG (Korea University, Korea)
Dong Yeob SHIN Dong Yeob SHIN (Yonsei University, Korea)
Yun Mi CHOI Yun Mi CHOI (Hallym University, Korea)
Symposium 2: Heterogeneity of Diabetes: From Pathophysiology to Precision Care Day 2, October 29(Fri), 2021 / 09:30-11:00 / Room 2 / LIVE Overview
Organizer: Seung-Hwan LEE (The Catholic University of Korea)
Although diabetes is currently classified into several broad categories, it is actually a heterogeneous disease with very diverse characteristics and prognosis. For example, even the patients with same type 2 diabetes may exhibit huge difference in the course, response to treatment, risk of complications, and others. Recently, with the genetic analysis, the development of precision medicine, and the introduction of new analysis techniques, efforts are being made to further subdivide the classification of diabetes.
In this session, Professor Robert WAGNER of Germany will lecture on the detailed classification according to the etiology of the high-risk group for type 2 diabetes, Professor Ronald MA of Hong Kong will lecture on the difference in the risk of individual diabetes complications, and Professor Su Heon KWAK of Korea will lecture on the study findings on rare monogenic diabetes using precision medicine. It is expected that through this session, you will be able to acquire the latest knowledge on personalized management of diabetic patients.

Chairperson : In Joo KIM (Pusan National University, Korea), Bong Soo CHA (Yonsei University, Korea)

Robert WAGNER 09:30-09:50 Pathophysiology-based Subphenotyping of Individuals at Elevated Risk for Type 2 Diabetes Robert WAGNER (University Hospital Tübingen, Germany)
Ronald CW MA 09:50-10:10 Interindividual Variations in Diabetic Complication Susceptibility Ronald MA (The Chinese University of Hong Kong, Hong Kong, China)
Soo Heon KWAK 10:10-10:30 Rare Monogenic Forms of Diabetes and Precision Medicine Soo Heon KWAK (Seoul National University, Korea)
Panel Discussion
10:30-11:00 Kyung-Soo KIM Kyung-Soo KIM (CHA University, Korea)
Sangsu KIM Sangsu KIM (Pusan National University, Korea)
Dong-Mee LIM Dong-Mee LIM (Konyang University, Korea)
Symposium 3: Incretin Biology: Basics and Applications Day 2, October 29(Fri), 2021 / 09:30-11:00 / Room 3 / LIVE Overview
Organizer: Obin KWON (Seoul National University)
Recently, in addition to the diabetes management effect, Incretin has been developed and is being developed as a drug used for intervention of various metabolic diseases. This session will discuss the latest study findings on the novel mechanism of incretin and its clinical applicability. Prof. Kevin WILLIAMS will describe the electrophysiological mechanism of GLP-1 in hypothalamic food-intake control neurons, Prof. Jonathan Campbell will present pancreatic cells and blood glucose control by GIP, and, lastly, Prof. Kun NA will present research on GIP and drug delivery system.

Chairperson : Ho-Young SON (The Catholic University of Korea, Korea), Young Min CHO (Seoul National University, Korea)

Kevin WILLIAMS 09:30-09:50 Glucagon-like Peptide-1 (GLP-1) Signaling in the Brain: From Neural Circuits and Metabolism to Therapeutics Kevin WILLIAMS (UT Southwestern Medical Center, USA)
Jonathan CAMPBELL 09:50-10:10 The Role of the Alpha Cell in the Incretin Effect and Postprandial Metabolism Jonathan CAMPBELL (Duke University, USA)
Pilgoo LEE 10:10-10:30 Photodynamic Therapy for Endoscopic Duodenal Resurfacing in Obesity Treatment Pilgoo LEE (Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Korea)
Panel Discussion
10:30-11:00 Obin KWON Obin KWON (Biochemistry and Molecular Biology, Seoul National University, Korea)
Tae Jung OH Tae Jung OH (Seoul National University, Korea)
Sungsoon FANG Sungsoon FANG (Biomedical Science, Yonsei University, Korea)
Symposium 4: Aging Skeleton Day 2, October 29(Fri), 2021 / 09:30-11:00 / Room 4 / LIVE Overview
Organizer: Serk In PARK (Korea University)
We organized a session with three major researchers who investigate the mechanism of osteocyte aging, which has recently been emphasized in the field of bone biology. Prof. Lynda F. BONEWALD, who is an expert in osteocyte research and served as the President of the American Society for Bone and Mineral Research(ASBMR), will talk about the aging mechanism of osteocytes along with the latest research trends on the mechanism of aging in the skeletal system. Prof. Maria ALMEIDA will share the results of years of research on the role of Sirtuin in the aging process of the skeletal system. Lastly, Prof. Ok-Hee JEON, who recently joined the School of Medicine in Korea University after completing doctoral and post-doctoral training courses at Johns Hopkins University and Buck Institute for Research on Aging, will share the data related to degenerative joint disease from the perspective of cellular aging.
Recently, sessions on the mechanism of aging in the skeletal system are being organized every year by the ASBMR(American Society for Bone and Mineral Research), and more and more researchers are paying attention on the research trends. As an effort to identify the aging mechanisms in molecular cell biology, research is being conducted according to the characteristics of each organ and cell. We believe that this session will serve as a chance to learn and understand the entire aging mechanism of the skeletal system.

Chairperson : Hyeong Kyu PARK (Soon Chun Hyang University, Korea), Soo Young LEE (Department of Life Science, Ewha Womans University, Korea)

Lynda F. BONEWALD 09:30-09:55 The Aging Osteocyte Lynda F. BONEWALD (Indiana Center for Musculoskeletal Health, USA)
Maria ALMEIDA 09:55-10:20 Mechanisms of Decreased Bone Formation with Aging Maria ALMEIDA (University of Arkansas for Medical Sciences, USA)
Ok Hee JEON 10:20-10:40 Cellular Senescence and Degenerative Joint Disease Ok Hee JEON (Department of Biomedical Sciences, Korea University, Korea)
Panel Discussion
10:40-11:00 Beom-Jun KIM Beom-Jun KIM (University of Ulsan, Korea)
A Ram HONG A Ram HONG (Chonnam National University, Korea)
Symposium 5: Novel Mechanisms of Central Metabolic Regulation Day 2, October 29(Fri), 2021 / 14:50-16:20 / Room 1 / LIVE Overview
Organizer: Sang Ouk CHIN (Kyung Hee University)
Since understanding how weight is controlled by the central nervous system is absolutely important for overcoming obesity and developing a treatment for obesity, studies in this field have been actively conducted in recent years. The first speaker, Professor Jong Woo SON of KAIST, will present a new study result showing that increased excitability of hypothalamic AGRP neurons leads to weight gain without changes in food intake. The second speaker, Professor Young XU of Baylor University in the US, will present the results of a study demonstrating the importance of hypothalamic melanocortin neurons in weight control in both humans and mice. The final speaker, Professor Weiping HAN of the National University of Singapore, will present an interesting study showing that not only hypothalamic neurons but also glia, non-neuronal cells, are involved in appetite regulation. It is expected that this symposium will provide an opportunity for learning and discussion to those who are interested in central nervous system metabolism.

Chairperson : Ja-Hyun BAIK (Department of Life Sciences, Korea University, Korea), Eun-Kyoung KIM (Brain & Cognitive Sciences, DGIST, Korea)

Jong-Woo SOHN 14:50-15:10 Increased Excitability of Hypothalamic AgRP Neurons Results in Increased Body Weight without Changes in Food Intake Jong-Woo SOHN (Department of Biological Sciences, KAIST, Korea)
Yong XU 15:10-15:30 Melanocortin Neurons and Body Weight Control in Mice and Humans Yong XU (Baylor College of Medicine, USA)
Weiping HAN 15:30-15:50 Direct Modulation of GFAP-expressing Glia in the Arcuate Nucleus Bi-directionally Regulates Feeding Weiping HAN (Institute of Molecular and Cell Biology, A*STAR, Singapore)
Panel Discussion
15:50-16:20 Min Soo KIM Min Soo KIM (Brain Research Institute, KIST, Korea)
Jaemin LEE Jaemin LEE (Department of New Biology, DGIST, Korea)
Chan Hee LEE Chan Hee LEE (Department of Biomedical Science, Hallym University, Korea)
Symposium 6: Lipid Management in the Era of Precision Medicine Day 2, October 29(Fri), 2021 / 14:50-16:20 / Room 2 / LIVE

Chairperson : Sung-Rae KIM (The Catholic University of Korea, Korea), SungHee CHOI (Seoul National University, Korea)

Sang-Hyun KIM 14:50-15:10 Lipid-lowering Therapy: Guidelines to Precision Medicine Sang-Hyun KIM (Department of Cardiology, Seoul National University, Korea)
Masahiro KOSEKI 15:10-15:30 Recent Advances in LDL-C Lowering Therapy in Familial Hypercholesterolemia Masahiro KOSEKI (Osaka University, Japan)
Sander KERSTEN 15:30-15:50 Role of Angiopoietin-like Proteins in Lipid Metabolism Sander KERSTEN (Wageningen University, Netherlands)
Panel Discussion
15:50-16:20
Hyun Jin KIM Hyun Jin KIM (Chungnam National University, Korea)
Jae Hyoung CHO Jae Hyoung CHO (The Catholic University of Korea, Korea)
Symposium 7: Metabolic Regulation of Energy Expenditure Day 2, October 29(Fri), 2021 / 14:50-16:20 / Room 4 / LIVE Overview
Organizer: Ki Woo KIM (Yonsei University, Korea)
Energy expenditure is an important factor in control of metabolic homeostasis. Through this session, we aim to deliver the latest research findings on the mechanism of energy expenditure controls by brown fat, hypothalamus, and leptin.
In this session, Prof. Su Myung JUNG will cover energy expenditure by brown fat and metabolic regulation, Prof. Wei SHEN will describe energy expenditure by hypothalamus, and finally Prof. Jose DONATO Jr. will discuss the interaction between leptin and energy expenditure.

Chairperson : Cheol Soo CHOI (Gachon University, Korea), Yun-Hee LEE (Department of Pharmacy, Seoul National University, Korea)

Su Myung JUNG 14:50-15:10 Understanding Brown Adipose Tissue Metabolism Using Multidisciplinary Approach Su Myung JUNG (Department of Biological Sciences, Sungkyunkwan University, Korea)
Wei SHEN 15:10-15:30 The Brainstem-Hypothalamic Circuitry Controls Body Temperature Wei SHEN (Shanghaitech University, China)
Jose DONATO Jr 15:30-15:50 The Role of Leptin Signaling in Early Life Jose DONATO Jr. (University of Sao Paulo, Brazil)
Panel Discussion
15:50-16:20 Sung-Yon KIM Sung-Yon KIM (Department of Chemistry, Seoul National University, Korea)
Jae Geun KIM Jae Geun KIM (Division of Life Science, Incheon National University, Korea)
MinWoo LEE MinWoo LEE (Soon Chun Hyang Institute of Medi-Bio Science, Korea)
Symposium 8: Personalized Medicine in Obesity Day 2, October 29(Fri), 2021 / 16:30-18:00 / Room 1 / LIVE Overview
Organizer: Jang Won SON (The Catholic University of Korea)
Obesity has reached epidemic proportions. Weight-loss outcomes with currently available therapeutic options are not only modest but also variable among patients. Precision or personalized medicine is an emerging arena that offers new opportunities to deal with this condition. These processes have led to partially understand some of the pathophysiologic processes involved in obesity and its clinical consequences, and have been targeted to individualize obesity therapy with some success. In this session, prof. Brian Piening will introduce an integrated multi-omics approach which has led to understanding some of the pathophysiologic processes involved in obesity. Secondly, prof. Cholsoon Jang will present innovative arterio-venous comparative metabolomics technologies to understand complex inter-organ metabolic interactions. Lastly, prof. Sang Youl Rhee will present recent advances in the digital therapeutic approach for personalized obesity management.

Chairperson : Soo LIM (Seoul National University, Korea), Byung-Wan LEE (Yonsei University, Korea)

Brian PIENING 16:30-16:50 Integrated Personal Omic Profiling for Obesity Brian PIENING (Providence, USA)
Cholsoon JANG 16:50-17:10 Quantitative Analysis of Metabolic Interactions between Mammalian Organs Cholsoon JANG (University of California Irvine, USA)
Sang Youl RHEE 17:10-17:30 Development of Personalized Digital Obesity Management Prototype Based on Artificial Intelligence Sang Youl RHEE (Kyung Hee University, Korea)
Panel Discussion
17:30-18:00 Ara KOH Ara KOH (Department of Life Sciences, POSTECH, Korea)
Jang Won SON Jang Won SON (The Catholic University of Korea, Korea)
Sunjae LEE Sunjae LEE (School of Life Sciences, GIST, Korea)
Symposium 9: Update in Primary Aldosteronism Day 2, October 29(Fri), 2021 / 16:30-18:00 / Room 2 / LIVE Overview
Organizer: Namki HONG (Yonsei University), Sang Ouk CHIN (Kyung Hee University)
In this adrenal session, we prepared a lecture to present the results of Korean and Italian studies on the establishment of an optimized treatment plan through multi-racial, multi-national studies and various genetic mutations related to primary aldosteronism (PA). In addition, we prepared a lecture where you can learn the results of several clinical studies to simplify the complex PA diagnosis process.

Chairperson : Choon Hee CHUNG (Yonsei University Wonju, Korea), Kyoung-Ah KIM (Dongguk University, Korea)

Jung Soo LIM 16:30-16:50 Aldosterone-regulating Receptor and Aldosterone-driver Mutation Jung Soo LIM (Yonsei University Wonju College of Medicine, Korea)
Gian Paolo ROSSI 16:50-17:10 The AVIS-2 Study: A Multiethnic International Survey of Clinical Outcomes of 1625 Primary Aldosteronism Patients by Adrenal Vein Sampling Gian Paolo ROSSI (University of Padova, Italy)
Fumitoshi SATOH 17:10-17:30 Next Clinical Practice of Primary Aldosteronism: Simplifying the PA Diagnostic Flow Fumitoshi SATOH (Tohoku University Graduate School of Medicine, Japan)
Panel Discussion
17:30-18:00 Kyoung Jin KIM Kyoung Jin KIM (Korea University, Korea)
Han Na JANG Han Na JANG (Seoul National University, Korea)
Dughyun CHOI Dughyun CHOI (Soon Chun Hyang University, Korea)
Symposium 10: Potential Molecular Mediators of Exercise Benefits in Diabetes Day 2, October 29(Fri), 2021 / 16:30-18:00 / Room 5 Overview
Organizer: Keun Gyu PARK (Kyungpook National University, Korea) / 박근규 (경북의대)
It has been well established that exercise is fundamental management for the patients with diabetes. However, the molecular mechanism by which exercise improves insulin resistance and glucose homeostasis in diabetes is still elusive. In this session, three outstanding speakers will unveil the novel potential players in the diabetes management stages. We believe that this session will broaden our understanding on the benefits of exercise in diabetes at molecular levels.0

Chairperson : Hyun Shik SON (The Catholic University of Korea, Korea), Hail KIM (Graduate School of Medical Science and Engineering, KAIST, Korea)

Jong-Sun KANG 16:30-16:50 Exercise Mimetics to Target Muscle Aging Jong-Sun KANG (Department of Molecular Cell Biology, Sungkyunkwan University, Korea)
Jun Hee LEE 16:50-17:10 Sestrins Mediate Metabolic Benefits of Exercise Jun Hee LEE (University of Michigan, USA)
Aimin XU 17:10-17:30 Gut Microbiota as a Molecular Transducer of Exercise Intervention for Diabetes Prevention Aimin XU (University of Hong Kong, Hong Kong SAR)
Panel Discussion
17:30-18:00 Dongryeol RYU Dongryeol RYU (Department of Molecular Cell Biology, Sungkyunkwan University, Korea)
Jae Man LEE Jae Man LEE (Department of Biochemistry and Cell Biology, Kyungpook National University, Korea)
Yeon-Kyung CHOI Yeon-Kyung CHOI (Kyungpook National University, Korea)
Symposium 11: Recent Advances in Thyroid Cancer Research Day 3, October 30(Sat), 2021 / 08:00-09:30 / Room 1 / LIVE Overview
Organizer: Won-Gu KIM (University of Ulsan)
In this session, we would like to introduce the latest basic and translational studies on thyroid cancer. First, Professor Rebecca SCHWEPPE (University of Colorado) will present the results of recent studies on the role of Focal Adhesion Kinase (FAK) in the progression and metastasis of thyroid cancer and the effectiveness of FAK-targeted therapy. The second lecture will be given by Professor Carmelo NUCERA (Harvard Medical School), a researcher who has been studying the microenvironment of thyroid cancer for a long time. She will introduce the importance of the cancer microenvironment and recent studies targeting this in thyroid cancer. Lastly, Professor Byung Cheol AHN (Kyungbuk Medical University) will present the latest study results on differentiation induction therapy, which can induce effective treatment by restoring intake of radioactive iodine in de-differentiated thyroid cancer. We expect this session to be an informative symposium on the direction of the latest study on thyroid cancer.

Chairperson : Minho SHONG (Chungnam National University, Korea), Won Bae KIM (University of Ulsan, Korea)

Rebecca SCHWEPPE 08:00-08:20 The Role of Focal Adhesion Kinase in Thyroid Cancer Rebecca SCHWEPPE (University of Colorado Anschutz Medical Campus, USA)
Carmelo NUCERA 08:20-08:40 Targeting Thyroid Carcinoma Microenvironment Carmelo NUCERA (Harvard Medical School, USA)
Byeong-Cheol AHN 08:40-09:00 Tailored Approaches to Restore Iodine Avidity in Dedifferentiated Thyroid Cancers Byeong-Cheol AHN (Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Korea)
Panel Discussion
09:00-09:30 Young Shin SONG Young Shin SONG (CHA University, Korea)
Min Ji JEON Min Ji JEON (University of Ulsan, Korea)
Sun Wook CHO Sun Wook CHO (Seoul National University, Korea)
Symposium 12: Lipid Metabolism and Complex Human Disease Day 3, October 30(Sat), 2021 / 09:40-11:10 / Room 1 / LIVE Overview
Organizer: Hyon Seung YI (Chungnam National University, Korea)
The understanding of lipid metabolism is one of the basic requirements for the prevention and treatment of the chronic diseases such as atherosclerosis, cardiovascular disease and diabetes. It also suggests new direction for diagnostic and therapeutic interventions for complex human disease.
In this session titled as ‘Lipid Metabolism and Complex Human Disease’, three speakers with extensive research experience will deliver lectures on the relationship between lipid metabolism and complex human disease.

Chairperson : Kyu-Chang WON (Yeungnam University, Korea), Seung-Hoi KOO (Department of Life Sciences, Korea University, Korea)

Takayoshi SASAKO 09:40-10:00 Role of ER Stress Response Failure in the Development of Steatohepatitis Comorbid with Diabetes Takayoshi SASAKO (The University of Tokyo, Japan)
Young-Bum KIM 10:00-10:20 Control of Leptin Transport by LRP or LepR Young-Bum KIM (Harvard Medical School, USA)
Goo Taeg OH 10:20-10:40 Immune and Vascular Networks in the Pathogenesis of Atherosclerosis Goo Taeg OH (Department of Life Sciences, Ewha Womans University, Korea)
Panel Discussion
10:40-11:10 Eun Hee KOH Eun Hee KOH (University of Ulsan, Korea)
Keun-Gyu PARK Keun-Gyu PARK (Kyungpook National University, Korea)
Eugene HAN Eugene HAN (Keimyung University, Korea)
Symposium 13: Functional Diversity in Adipose Tissue Day 3, October 30(Sat), 2021 / 09:40-11:10 / Room 2 / LIVE Overview
Organizer: Ki Woo KIM (Yonsei University, Korea)
Physiological and metabolic control mechanism of adipose tissue is the field that needs to be studied in order to understand various functions of adipose tissue. In this session, we would like to follow the latest knowledge on various functions of pre-adipocyte and the epigenetic regulation mechanism of adipose tissue through three experts of adipose tissue.
In this session, Prof. Takeshi INAGAKI will cover the effect of epigenomics of adipocyte on its function, Prof. Rana K. GUPTA will give a lecture on various functions of pre-adipocyte, and lastly, Prof. Myung Gon KO will discuss the relationship between DNA methylation and characteristic function of adipocytes, and its mechanism.

Chairperson : Jae-woo KIM (Department of Biochemistry and Molecular Biology, Yonsei University, Korea), Myung-Shik LEE (Biomedical Science Institute, Yonsei University, Korea)

Takeshi INAGAKI 09:40-10:00 Epigenetic Regulation of Adipose Cell Fate and Function Takeshi INAGAKI (Gunma University, Japan)
Rana K. GUPTA 10:00-10:20 Functional Diversity of Adipocyte Progenitors  Rana K. GUPTA (UT Southwestern Medical Center, USA)
Myunggon KO 10:20-10:40 Ablation of TET Proteins in Adipocytes Protects Against Adiposity by Potentiating Energy Expenditure Myunggon KO (Department of Biological Sciences, UNIST, Korea)
Panel Discussion
10:40-11:10 Jiyoung PARK Jiyoung PARK (Department of Biological Sciences, School of Life Sciences, UNIST, Korea)
Jae Myoung SUH Jae Myoung SUH (Graduate School of Medical Science and Engineering, KAIST, Korea)
Kae Won CHO Kae Won CHO (Soon Chun Hyang Institute of Medi-Bio Science, Korea)
Symposium 14: Hormonal Aspect of Musculoskeletal System Day 3, October 30(Sat), 2021 / 09:40-11:10 / Room 3 / LIVE Overview
Organizer: Beom-jun KIM (University of Ulsan)
As we rapidly move towards a super-aging society, the researches on bones and muscles, which are the largest organs in our body, are being actively conducted to overcome osteoporosis and sarcopenia. Especially due to the fact that bones and muscles secrete various factors such as osteokine and myokine, their roles as not only simply protecting internal organs and enabling movement but also an endocrine organ regulating the homeostasis of our body, are attracting worldwide attention. In this session, we aim to examine the critical action of well-known musculoskeletal-derived factors, including sclerostin, osteocalcin, and lipocalin-2, on insulin resistance, obesity, and nonalcoholic steatohepatitis, and to discuss the importance of bone and muscle in controlling metabolic diseases.

Chairperson : Chan Soo SHIN (Seoul National University, Korea), Je-Yong CHOI (Department of Biochemistry and Cell Biology, Kyungpook National University, Korea)

Ryan C. RIDDLE 09:40-10:05 Endocrine Actions of Sclerostin Ryan C. RIDDLE (Johns Hopkins University, USA)
Gyuri KIM 10:05-10:25 Impact of Skeletal Muscle on Metabolic Health Gyuri KIM (Sungkyunkwan University, Korea)
Patricia DUCY 10:25-10:50 Bone Regulation of Insulin Secretion and Glucose Homeostasis Patricia DUCY(Columbia University Medical Center, USA)
Panel Discussion
10:50-11:10 Sang Wan KIM Sang Wan KIM (Seoul National University, Korea)
Ji Hyun PARK Ji Hyun PARK (Jeonbuk National University, Korea)
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