Organizer: Junghyun NOH (Inje University)
Several hormones are known to involve in aging process. On the other hand, organ and cellular senescence results in changes of many endocrine functions. In this session, experts on aging and endocrine function research will review the interrelationship between senescence and endocrine regulation. The session is composed of three topics as 1) aging and changes in water balance, 2) ovarian aging and reproductive longevity, and 3) targeting β-cell senescence and its senescence-associated secretory phenotype.

Organizer: Dong Jun LIM (The Catholic University of Korea)
Subclinical hypothyroidism, which means increased serum TSH with normal free T4, is a common clinical situation and sometimes is a challenge to the decision of thyroid hormone. Dr. Naoki HATTORI will introduce the role and clinical pitfalls of macroTSH in subclinical hypothyroidism and treatment issues.
Recognizing the relationship between thyroid autoimmunity represented by increased thyroid peroxidase (TPO) antibody (Ab) level and thyroid dysfunction is very important to clinicians who decide their treatment on pregnant women. Dr. Tim I.M. KOREVAAR will present clinical characteristics of TPOAb-positive pregnant women and guide clinical decisions of thyroid hormone treatment in pregnant women with thyroid dysfunction.
Two approved tyrosine kinase inhibitors (TKIs), sorafenib and lenvatinib, are available for the treatment of radioiodine-refractory advanced or metastatic differentiated thyroid cancer (DTC) but which one is better as first-line therapy is still challenging. Dr. Won-Gu Kim will present this issue based on his extensive clinical experiences and previous literature on two TKIs.

Organizer: Cheol Ryong KU (Yonsei University)
The Rare Disease Research Group prepared a symposium to form an international network to overcome rare endocrine diseases under the theme of “Standing Together Against Endocrine Rare Disease”. Professor YOSHIZAKI will give a lecture on the case of establishing an international network of rare diseases starting in Japan, and Professor FALHAMMAR will give a lecture on his experience in establishing a cohort of patients with congenital adrenal hyperplasia in Europe. Lastly, Professor Sang Wook JIN prepared a lecture on his experience of building a Cushing's disease registry for Koreans.

Organizer: Dong Jun LIM (The Catholic University of Korea)
Insulin-like Growth Factor-1 (IGF-1), a major regulator of human tissue, is mostly produced by the liver and reflects the sum of growth hormone (GH) levels. Serum IGF-1 concentration has many confounding factors such as age and gender and measurement of IGF-1 is very important to the diagnosis of acromegaly in adults as well as GH deficiency in a child. Dr. In-Kyung Jeong is an expert who has been interested in normal IGF-1 levels of the general population and will give a lecture about physiologic roles and reference ranges of IGF-1 in a Korean population.
Discordant results between GH and IGF-1 in acromegaly frequently give confusion to physicians who are willing to decide the diagnosis or treatment of acromegaly. In this context, Dr. Hidenori Fukuoka, an expert in pituitary tumor management, will talk about the interpretation and management of mismatched results between GH and IGF-1 levels in patients with acromegaly.
In this session, Dr. Nicholas A Tritos, an international expert in the management of acromegaly, will share his experience and guide us through GH receptor/IGF-1 targeting to the best treatment in acromegaly.

Endocrine-disrupting chemicals (EDCs) are now thought to be responsible for a variety of human diseases. In particular, metabolic and reproductive disorders are known as representative diseases greatly affected by EDCs. However, it is very difficult to identify the cause and approach the treatment because the kinds of EDCs and the mechanism of action in the body are very diverse. At this SICEM 2021, 3 representative speakers will present about AhR, one of the main mechanisms of EDCs action, the mechanism of transgenerational effect of EDCs and the latest research on EDC and diabetes.

Organizer: Sihoon LEE (Gachon University)
The theme of this Special-interest Group session is “PTH and Regenerative Medicine”. Professor GILD of the Royal North Shore Hospital in Australia discovered a new mutation in the mature PTH coding region in a patient with congenital hypoparathyroidism. With this, she will provide clues to the molecular function of the PTH gene and discuss international research cooperation on the rare genetic diseases. Professor HOJO of the University of Tokyo, Japan, will share the overall details and new study findings on bone regeneration treatment. In addition, Professor In Bo HAN, a neurosurgeon spine specialist and researcher in CHA School of Medicine, will introduce the study findings and case studies using PTH and stem cells. It is expected to be an interesting and informative lecture.

Organizer: Ohk Hyun RYU (Hallym University)
Current prognostic markers in adrenal cortical carcinomas (ACCs) have limitations in identifying patients with a poor prognosis and who require adjuvant therapy. Professor Jung Hee Kim will introduce new prognostic biomarker candidates of ACCs using mass-spectrometry-based proteomics and machine learning algorithm.
Aldosterone measurement is the key step for diagnosis of primary aldosteronism (PA). There are several methods (LC-MS, RIA, chemiluminescent enzyme immunoassay) that determine the value of aldosterone. To compare the value between methods, standardization or harmonization process is necessary. Professor Tetsuo Nishikawa will introduce standardization process and related study data for aldosterone in Japan.
Autonomous cortisol secretion (ACS) is the most common hormonal alteration in adrenal incidentaloma (AI). Professor Massimo Terzolo will address brief overview of recent data, critical review of the interventional data, and the possibility of medical treatment (inhibitors of steroid synthesis or action) in ACS.